I've been typing on Dvorak for about 15 years. As others have already said, it makes typing fast and smooth.
You will have to memorize the entire keyboard by feel. The buttons will no longer do what they say. The punctuation, including [] and +\, moves, too. That can be a good thing, since you can look at what you type, and not at your fingers. It does mean that keyboard commands and passwords also move around. I can type with one hand or one finger (such as if I'm holding something in the other hand), but it's not a good way to enter anything.
I do NOT recommend it if you frequently use others' computers (e.g. you work in IT) or if you frequently use public computers (school, library, etc.). I also do not recommend it if others must frequently use your computer.
I only lately switched my (Android) phone over to a Dvorak. It's odd, with an on-screen keyboard, seeing what I'm doing. Still, the principle is the same, and if I think about how the words are "shaped" for me, instead of where to find a given letter, it seems to be just a little easier. It is a little odd doing one-finger, gesture typing back and forth across mainly the home row.
Here's an oldie but goodie, the resource I used to learn:
http://gigliwood.com/abcd/One more note: if this is about ergonomics, be sure you fix your bad habits regardless of which keyboard layout you end up using. Use a keyboard that fits you, and put it at a good height and angle. Lift or support your wrists so they're straight and relaxed, and not resting on any hard, sharp edges. And install and adjust a tool such as Workrave to remind yourself to take periodic breaks. There are loads of ergonomics guides online.
Good luck!