I understand you may not want to give details of just where this road is...but there is a section of interstate that every time I've driven, I've seen someone do something so reckless it could cause an accident (crossing multiple lanes in order to take an exit is the last example...they barely missed hitting anyone and nearly got the barricade...another time someone hit the barricade for no good reason, just not paying attention, another time...). Anyway, I just avoid that section. If we're talking a mile or five section, could you do the same? If we're talking a long stretch...well, one accident coming OR coming in, say, a 60 mile stretch isn't that bad. Regardless of what vehicle you have, the best way to survive an accident is to avoid it in the first place.
That said, I'd rely on safety ratings. Make sure you can see well when driving that vehicle. You want a good bit of power to quickly maneuver out of the way (electric cars tend to be pretty good at this, the older Prius I used to have wasn't too shabby in Sport mode, maybe keep it in that mode when on this stretch of road?). But yeah, all else equal, the bigger the vehicle the safer YOU are. It becomes a bit of a game of chicken, but that's not what you asked.