High fees are generally associated with actively managed funds that will often charge over 1% and sometimes 1.5% and higher. 0.25% is not an expensive fund. I appreciate it is higher than a fund that charges 0.07%. However you are not comparing like for like here. VUSA is invested in approximately 500 US stocks while VWRL is invested in more than 3000 globally. Given the choice I would rather pay the 0.25% and have exposure all around the world.
I believe most US based people would not solely invest in an S&P 500 fund because it would limit them to the largest US corporations and they would miss out on some of the smaller and mid sized companies that may go onto become giants in the future. The US Equity Index fund (0.1%) is a better choice here than VUSA as it invests in over 3500 US companies, spreading the risk and the types of companies you are invested in. This one is a bit more similar to the US Total Market Fund (VTSAX) that US forum members will discuss on here, or that JL Collins mentions in his stock series. However as good as the UK version of this fund is, I don't personally think a UK person should be invested 100% in the US.
So to go the global route you really have two choices. Pick the cheaper Europe, US, UK, Emerging Markets, Japan and Asia Pac trackers and allocate to them in the proportions that a global tracker would i.e. usually based on market cap, or just go for simplicity and pick a global tracker such as VWRL.
You are completely correct that fees are important but we are not talking about the difference between a 2% fund and a 0.07% fund here.