Wow. Those options are ... not good. I had to look up the "Nuveen Equity Index R3" to confirm that it is, indeed, an S&P 500 index fund with an expense ratio of .86%. For reference, my 401(k) offers Fidelity's Spartan S&P 500 index fund at an expense ratio of .07% to do the exact same thing. Not bragging, just wondering how in the world they justify charging so much to just follow a very basic index.
Well, if all your horses are donkeys you might as well pick the tall one. I'd say use the Nuveen Equity Index R3 for your large cap domestic, and "Bny Mel Dl Sm Cap Stock Ind R" (which is indeed a Russell 2000 index with a .84% ratio) if you want to put some small caps in as well. I have no idea what your preferred asset allocation is, but those seem like the least bad choices you have. There's "Bny Mel Dl Agg Bond Index R" in there for bonds as well.
I was going to say with higher fees you might as well check out the actively managed funds as well. But they've still got a .5% higher premium, so there doesn't seem much point.
Fortunately, most of building a stash is about savings, and only a little bit about investing. And higher fees in a 401(k) will still usually beat paying income tax and then using an after-tax account. So I'd still do it. But, after getting any match your company does, I'd definitely fill the Vanguard IRA first.
And see if you've got any investment savvy co-workers who might be willing to join you and go to your company management and ask about getting a better deal. That depends on how approachable your company is to stuff like that, of course. It's part of compensation, so no different than asking for a raise, I figure.