The gist of it is that they look at quitting something -- a job, a relationship -- while analyzing sunk and opportunity costs from an economic perspective. Often people under-emphasize the upside of quitting (sometimes by over-emphasizing the sunk costs of those choices.) There are several interviews with famous "quitters" -- athletes, public figures, average people. The discuss the psychological implications and strategies for moving on.
The podcast is free and can be downloaded at the link I provided.