If you're going to have 2-3 kids, depending on your timeline you may be talking three car seats, which is fine but takes up most of your interior space. If you still need to carry strollers and general kid stuff on your travels, you might want to at least look at the Camry, or even think about going up to the Sienna (minivan) or maybe a RAV-4 or Highlander if you prefer SUVs.
I like Honda, but long term I don't think their automatic transmissions are as reliable as Toyota's. My sister is still driving her '97 Honda Odyssey, but she did have to replace the transmission at around the 90k mile mark.