It shouldn't be too hard to calculate...
Is the fee from the store, or an extra charge in paying your bill, or something like that? Anyway, I'm assuming you are trying to hit a min. spend for a sign-up bonus. If you had a straight up 2% cash-back card, this math would be very easy (and I'd be saying not to pay a 2.35% fee with it). Try to figure out the redemption value of your points. I think as a general rule of thumb, divide your points by 100 and that is your minimum cash value of your points. For example, if you are getting 50K points on a Chase Sapphire Preferred, that can be turned into a minimum of $500 (hopefully much more if you use it right).
With a sign-up bonus, it almost always makes sense to do whatever possible to meet the min. spend. If you don't spend enough, you get nothing.