The biggest challenge for the majority of new agents is making enough sales so that you actually make some money to be smart with...A very large percentage of new agents are gone within a year. Being an RE agent isn't so much about real estate, it is about selling successfully.
You and your wife need a business plan with specific goals and how you are going to achieve them (i.e. have meetings with X number of prospective sellers (and a much smaller number of buyers) per week/month). Good luck!!
Don't forget to put money away for taxes once she starts making a profit ("both sides" of Social Security...).