You can't unsubscribe to work-wide distribution lists.
And if they are "reply-all" issues, it's not going through a list anymore, it's going to your email.
Perhaps my favorite "forget to use BCC" ever was from a secretary at my dance school. She sent an email to every single client. Did not BCC, so all the emails appeared, but since they were in the "to" line, you mostly didn't see them. Her boss replied all with "In the future, make sure to use the BCC line, if you havenít already gotten some snippy responses about sharing peopleís email, they will be coming.".
Not only did he stupidly use reply all, but because his email was the reply, every single address now appeared in the text of his email, AND the "to" line.
Idiot. Way to make the mistake you were shaming for.